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Clinical research priorities include properly designed human clinical trials with adequate sample sizes, appropriate controls, and validated outcome measures

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More and more, researchers are discovering that the microbes that control our digestive system can also control our neurobiology, or the gut-brain neuroendocrine metabolic axis

The stress factor is also relevant in the prenatal period since babies of mothers with high stress reported high concentrations of salivary cortisol during pregnancy and had a significantly higher relative abundance of Proteobacteria and a relative abundance of minor lactic acid bacteria ( Lactobacillus , Lactococcus , Aerococcus , and Bifidobacteria )