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Waxing can also cause darkening if it's too hot

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doi: 10.1038/ki.2012.345 158 VaziriN

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Mechanistically, Oteseconazole, like other triazoles, inhibits 14-demethylase in the fungal cytochrome P450 system, thereby disrupting ergosterol biosynthesis, an essential component of fungal cell membranes (Hoy, 2022)