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In ME/CFS and Long COVID, researchers have identified a 'mitochondrial-peroxisomal vicious cycle.' As mitochondria attempt to generate adenosine triphosphate (ATP) for energy, damaged electron transport chains 'leak' electrons, creating highly reactive superoxide radicals

Elamin Y, Gomez D, Papadimitrakopoulou V, Tran H, Rinsurogkawong W, Lewis J, Landry L, Roarty E, Lee J, Roth J, Swisher S , Zhang J, Heymach J