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The only therapeutic approach currently in clinical trials is AAV2-BDNF gene therapy, which requires neurosurgical implantation

Aigner, T., Haag, J., Martin, J

Critics say theres still insufficient human safety and efficacy data for widespread use

The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)