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Although there have been extensive studies on the cellular and molecular mechanisms of AD, such as amyloid accumulation and neuroinflammation, few have been framed under the context of NPS (Krell-Roesch et al., 2019
Furthermore, vitamin C is an antioxidant that can neutralize free radicals, which are increasingly found in the organism during oxidative stress
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GHK-Cu suppresses inflammation through multiple signaling pathway interventions, reducing production of pro-inflammatory cytokines like TNF-alpha and IL-6 while decreasing inflammatory cell infiltration into tissues
When functionalized with fluoride ions (F - ), these systems exhibit synergistic antimicrobial-remineralizing dual functionality, presenting a promising strategy for secondary caries prevention and therapy (Qi et al., 2025)
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