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However, since a larger fraction of the total drug in the body is now free, the steady-state concentration of free drug increases significantly, posing a major risk of toxicity

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This is particularly relevant for injectable formulations obtained outside standard pharmaceutical channels, where risks of contamination, endotoxin exposure, or improper compounding may exceed any theoretical biologic effect

Reconstituted peptide doses are typically tiny volumes often a fraction of the syringe

Pharmacological responses to Cagri and related peptides Cagri has been broadly profiled in pharmacological assays of cells transiently transfected with CTR, CTR/RAMP1 or CTR/RAMP3 21

Drug Design, Development and Therapy, 9, 2485-2499