References: King M
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Immune effects are restorative, not overstimulating: It rebalances T-cell ratios, upregulates IL-2 in aged tissues, and improves neuroimmune integration, suggesting a targeted recalibration of immune tone rather than indiscriminate boosting. It restores circadian and hormonal rhythms: By stimulating melatonin synthesis, protecting pineal structure, and re-entraining clock genes, Epitalon may counter the widespread circadian drift of aging, with implications far beyond sleep, touching immunity, metabolism, and neuroprotection
TLR4, rather than TLR2, regulates wound healing through TGF-beta and CCL5 expression
Upregulated genes were enriched in pathways related to T cell differentiation and activation (for example, RUNX3 , IFNG , TNFSF9 ), negative regulation of the immune response (for example, WASL , ID2 , TNFAIP3 ) and circadian regulation of gene expression (for example, RORA , PER1 , NRIP1 ) (Fig
