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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

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The response curves show that most participants were still losing weight at week 68, suggesting that longer treatment durations might produce even greater reductions

doi: 10.1038/s42003-025-08067-y 334 FangSLuYHuangYZhouHFanX

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Adesina SE, Porter KM, Hart CM, Sutliff RL (2012) Hypoxia increases endothelial cell reactive oxygen species production and reduces thioredoxin 2 levels