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Figure 6 Th1 cells may also contribute to the development of this advanced inflammatory state, although the available evidence is less consistent than for Th17 cells

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Mitophagy, in particular, serves as a key mechanism for maintaining metabolic homeostasis by selectively removing damaged mitochondria and limiting the accumulation of ROS [47].In CRC, the PINK1Parkin-mediated mitophagy pathway and Drp1-driven mitochondrial fission have been shown to act in concert to preserve mitochondrial quality under chemotherapeutic stress [48]

Nat Rev Chem 5(9):595597

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For best results, moderation and timing matter more than eliminating alcohol entirely