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Cancer epidemiology, biomarkers & prevention : a publication of theAmerican Association for Cancer Research, cosponsored by the AmericanSociety of Preventive Oncology
This is supported by a mouse study where effects on skin extensibility and elastic recoil were measured
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
The B12-intrinsic factor complex travels to the terminal ileum where specific receptors mediate absorption
It works synergistically with preservatives and helps to improve water-resistance of sunscreens
