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Biomolecules , 12 , 125

PI3K/Akt/mTOR activation Hits the central anabolic signalling cascade - the same pathway behind insulin's metabolic effects and most growth-factor-driven hypertrophy

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However, these same protective mechanisms create a major pharmacological bottleneck, particularly for biologics such as antibodies, enzymes, and nucleic acid-based therapeutics exceeding 400-500 Da

Sulfotransferases are enzymes which catalyse the transfer of sulfate from PAPS to the xenobiotic molecule [12]