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Plant and Animal Genome Conference, 2015

Ebselen and analogues: pharmacological properties and synthetic strategies for their preparation

This challenge arises because levodopa undergoes extensive peripheral metabolism, reducing the amount of drug that reaches the brain 52

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As loss of ATM correlates with decreased pigmentation in hair follicle melanocytes it is difficult to determine if loss of melanin contributes to a reduction in ATM expression or drives the process of ATM loss more rapidly