Indeed, a kynurenine-derived metabolite, quinolinic acid, influences neuronal activities and causes neurotoxicity (150, 151)
These effects are usually short-lived and improve with rest, fluids, or electrolyte replacement
doi: 10.1080/10408398.2022.2131729 264
SCFAs are capable of traversing the blood-brain barrier to modulate central nervous system (CNS) activity, while dysregulation of microbiota-derived neurotransmitters, such as gamma-aminobutyric acid (GABA) and dopamine, is implicated in CNS disorders, including schizophrenia 35
Thats where glutathione steps in - it sits inside the mitochondria like a live-in cleaner, mopping up reactive oxygen before it can cause chaos
2011;10(Suppl 2):S605