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examined the administration of a commercial oral supplement with hydrolyzed fish cartilage on skin attributes in a double-blind, placebo-controlled clinical study in 2021 from Brazil [35]

KRAS mutations reprogram cancer metabolism, resulting in increased glucose uptake and glycolysis [7], altered glutamine/glutamate metabolism [8, 9], abnormal mitochondrial activity and redox equilibrium [1012], which are critical for the increased energetic, biosynthetic, and redox requirements of tumor cells and therefore required for KRAS- induced tumorigenicity [13, 14]