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First, acute and chronic EtOH administration induce overproduction of ROS, RNS and other free radicals, observations made in cell cultures, experimental animals and human subjects

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doi: 10.1016/S1350-9462(99)00009-9

Obesity is characterized by a chronic low-grade inflammatory state with increased secretion of inflammatory cytokines including TNF (175)

Maintain an audit log of lot, reconstitution date, and storage conditions per laboratory protocol