In contrast, GSTP1 promotes ER stress-induced apoptosis in liver cancer by glutathionylating SERCA, thereby inhibiting pro-survival MAPK8 signaling 50
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Furthermore, in spite of considerable research efforts (Dixon et al., We propose a model describing the diverse roles of plant GSTs in the interactions of plant hosts with pathogenic microbes considering four different plant-pathogen interaction types (Table 1): (1) symptomless resistance (including basal resistance to bacteria and symptomless R gene-mediated resistance to viruses), (2) HR-associated resistance, (3) limiting susceptibility to systemic spread of pathogens and plant cell/tissue death (during infections by hemibiotrophic/necrotrophic fungi, bacteria, and viruses), (4) promoting susceptibility to biotrophic fungi and viruses (maintaining reduced conditions in infected non-necrotic plant tissues)
Depending on the intended effect, peptides can be administered orally, intravenously, or topically
