Cyanocobalamin : Synthetic form, requires conversion to active B12, longer shelf life, lower cost Methylcobalamin : Bioactive form, immediate utilization, preferred for neurological symptoms, more expensive Hydroxocobalamin: Used for cyanide poisoning, longest-acting Standard dose: 1000mcg/ml Routes: Deep IM (gluteal/deltoid) or subQ (abdominal) Loading phase: Daily/weekly for 1-4 weeks Maintenance: Monthly or every 3 months (hydroxocobalamin) No need for aspiration before injection Oral absorption requires intrinsic factor (absent in pernicious anemia) and healthy ileum
Together, these components utilize NADH to reduce haem iron [19,20]
[DOI] [PubMed] [Google Scholar] 103.Zhang J., Zhou R., Cao G., Zhang Y., Xu H., Yang H
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications
Kanamori et al
Glutathione is often called the bodys master antioxidant. It is a powerful substance naturally produced by your liver and found in every cell