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As for BW reduction, semaglutide 2.4 mg appeared as even more beneficial on glucose metabolism 73

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Its gut-healing properties may address the GI component common in fibromyalgia

The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

Human evidence is limited to a two-person IV safety pilot with no control group or efficacy endpoint, an unpublished 20152016 U.S