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A specific gain-of-function mutation in the Nlrp3 gene is a marker of auto inflammatory disorders 23,24

RakariyathamKYangXGaoZSongMHanYChenXet al

More importantly, NK cells further damage melanocytes by secreting IFN-, recruiting adaptive immune responses, and aggravating melanocyte destruction

288,289,290 When cells produce proteins, they clear improperly folded or redundant proteins to maintain intracellular protein homeostasis

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It combines with many toxic substances and converts them to less harmful forms, which are then excreted from the body