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PIH results from stimulation of melanocytes and overproduction of melanin in the epidermis in response to cytokines, chemokines released during inflammation

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This typically becomes noticeable 2 to 3 weeks after the final dose, when circulating retatrutide levels have dropped below the therapeutic threshold

In the controls, the lesion area was still large, along with edema, necrosis of muscle fibers, and acute inflammation with foci of abscessation

However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference