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General safety observations from published health sources show: Oral glutathione is well tolerated in moderate doses Long-term use does not suppress natural production No evidence suggests dependency or rebound effects Side effects are rare and usually mild Mild side effects, when they occur, may include bloating or headache, often linked to excessive dosing rather than duration of use

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At a dose of 800 mg/kg for 0.5 h, all mice died

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