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10.1016/j.jpedsurg.2015.03.001 76

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Androgen-dependent expression of FcgammaRIIB2 by thyrocytes from patients with autoimmune graves' disease: a possible molecular clue for sex dependence of autoimmune disease

A small fraction of an ingested dose is metabolized in the liver by the cytochrome P-450 mixed function oxidase enzyme system to form a reactive, potentially toxic, intermediate metabolite which preferentially conjugates with hepatic glutathione to form the nontoxic cysteine and mercapturic acid derivatives which are then excreted by the kidney