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Mayo Clinic Proceedings: Innovations, Quality & Outcomes

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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores

It also reduces the secretion of transforming growth factor-beta1 in fibroblasts, an important step in countering the negative effects of DHT

2.55 mg per day (subcutaneous in this framing), once daily or split as 2.5 mg twice daily