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showed that direct intra-ovarian transplantation of bone-marrow-derived MSCs restored estrous cycling, revived estrogen secretion and cut granulosa-cell apoptosis in cyclophosphamide-injured rats, effects linked to paracrine VEGF, HGF and IGF-1 release [167]

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329 The ability of sHSPs to engage a wide range of aggregation-prone proteins, coupled with their rapid upregulation in response to cellular stress, positions them as critical first responders in neurodegenerative proteostasis

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