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Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA
Headache Pain 63 VgontzasA.PavloviJ
In complex chronic conditions like Long COVID, the elegant and highly regulated machinery of cellular energy production is frequently thrown into absolute chaos
Reference Protein and Structure Sequence P00390 (1.8.1.7) (Sequence Homologues) (PDB Homologues) Biological species Homo sapiens (Human) PDB 2gh5 - Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5 (1.7 ) Catalytic CATH Domains 3.30.390.30 3.50.50.60 (see all for 2gh5) Cofactors Fadh2(2-) (1), Glutathione (1) Enzyme Reaction (EC:1.8.1.7) Alternative enzyme names: GSH reductase, GSSG reductase, NADPH-GSSG reductase, NADPH-glutathione reductase, NADPH:oxidized-glutathione oxidoreductase, Glutathione S-reductase, Glutathione reductase, Glutathione reductase (NADPH), Enzyme Mechanism Introduction Initially, the enzyme is in the oxidised state, with its redox active cysteines 58 and 63 forming a disulphide bond to each other
The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies
