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Ceramide generation was a critical component of Fas receptor-induced eryptosis, whereas therapy with natural organosulfur compounds inhibited the apoptotic death of erythrocytes by antagonizing oxidative stress and the Gardos channel that led to suppression of ceramide-initiated Fas aggregation in lipid rafts of these erythrocytes

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Today, a vast number of studies have reported the important active constituents and the main mechanisms of action involved in the anxiolytic, sedative, anticonvulsant, antidepressant, and antipsychotic properties of some species of passionflowers [132], with imperatorin, passiflorine, maltol, and baicalin as some of the key components