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The FDA regulates substances to ensure they meet safety and efficacy standards, and ipamorelin did not reach said standards

Aberrant methylation changes are also known to alter the structure and function of DNA and histones during cancer development (39)

Plasmid transfection and luciferase reporter assay The luciferase-based reporter plasmids pNFKB-Luc and pTA-Luc (Takara Bio, San Jose, USA) were applied with Lipofectamine 2000 (Thermo Fisher Scientific) according to the manufacturers instructions

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