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17 The excess accumulation of hydrogen peroxide is damaging to macromolecules such as DNA, protein, and lipids, leading to organelle damage (especially mitochondria 18 ), cellular damage, tissue damage, and ultimately organ damage

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Inherited mutations in the gene (ADK) encoding adenylate kinase are also associated with hypermethioninemia

Alves R, Ferreira CGM, Silva MVda, Vieira Filho LD, Silva Junior VAda, Melo IMFde, et al