Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
Gamma Aminobutyric Acid (GABA) - Helps to promote production of calming neurotransmitters
tolerance-free sleep promotion
The rash is usually maculopapular, but lesions are polymorphous and can present as plaques, blisters, target-like lesions, urticaria, exfoliation, eczema, or, rarely, lichenoid eruptions (Figure 2)
Discard if discoloration, cloudiness, or precipitate develops
2022
