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Local ice has been shown to help (for not more than 10 minutes at a time, to avoid skin damage)

When it kicks into gearwhether from fighting an infection, recovering from intense exercise, or healing from surgeryit needs a steady supply of fuel to keep white blood cells working to protect your body from damage

Pain fibers are in the skin, and going through the skin too slowly or too forcefully may increase the pain

High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

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When more free radicals than antioxidants are present, oxidative cell damage occurs