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It could point to several things: A different cause: your fatigue might stem from thyroid problems, iron deficiency, or sleep apnea rather than B12

A 280-pound person and a 160-pound person often use the same dose

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Other studies show that calcium oxide crystals induce mitochondrial dysfunction in macrophages.[ref][ref] High dietary oxalate intake causes some, but not all, people to have statistically significant decreases in mitochondrial metabolic function.[ref] Animal models of high oxalate levels show that there is an increase in mitochondrial reactive oxygen species (ROS) that can lead to oxidative stress if glutathione is inadequate