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Ligation of PD-1 with PD-L1 or PD-L2 inhibits the signal transmitted from activated T lymphocytes and reduces the expression of pro-inflammatory cytokines and anti-apoptotic molecules

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The chemical concentration and treatment duration for each assay were set in accordance with the protocols used in our previously published studies 17,18,19 or pilot studies

Compared to conventional liver injury diagnostic methods, such as invasive tissue biopsy, ex vivo blood analysis and previously reported fluorescent/optoacoustic probes, BTPE-NO 2 @F127 offers real-time, in situ monitoring with high sensitivity and signal-to-background ratio, as well as mutually corroborating signals for increased reliability

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