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By iteratively tweaking the active site using advanced computational tools and expressing and testing the resulting enzyme, Pultzs team identified a design that balanced maximal activity toward both peptides simultaneously

Ethnomedically, the Physic nut is used as an anti-HTN in Ethiopia (93) and Cameroon (330) and as a diuretic elsewhere (332)

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Proc Natl Acad Sci USA 1993

It appears to ensure that the actin reserve is well maintained for use by fibroblasts in their extended lifespans