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Retinol's forced turnover on already-compromised skin often causes more problems than it solves, especially at over-the-counter concentrations where efficacy is lower but irritation persists

Patel 2012)

95% CI, 1.01-1.09

Interestingly, BCRP is expressed at significantly higher levels than Pgp in the human BBB, whereas the opposite is observed in the rodent BBB (175)

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The hypocretin/orexin neuropeptides are essential for the maintenance of wakefulness and the suppression of REM sleep, and zebrafish possess a functional hcrt-pineal gland circuit, connecting the hcrt and melatonin systems together in sleep consolidation (Appelbaum et al