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Puerarin protects retinal cells against apoptosis by antioxidant mechanisms such as lowering iNOS expression, increasing superoxide dismutase (SOD) activity, and preventing the production of advanced glycation end products (AGEs)

Pesce et al suggested that such interaction enhances the immune response, fostering a more coordinated and effective defense against the infection and typically resulting in milder symptoms and mitigating the effects of the virus more effectively

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In the presence of GSH, glutathione-S-transferase activity detoxifies xenobiotics and various physiological metabolites to form mercapturates and reactivated glucose-6-phosphate dehydrogenase [6]

Another limitation is that all these studies were conducted using spike protein rather than a live virus for practical reasons

Also, in type 2 diabetes mellitus patients, impaired zinc homeostasis leads to uncontrolled expression of immune mediators, such as IL-1, IL-6, and NF-B, which at the same time simultaneously exacerbate the immune response and lead to pathogenesis, negatively affecting -cells