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More importantly, PKM2 can translocate into the nucleus, where it regulates the transcription of metabolic genes such as HIF-1, LDHA, and GLUT1, thereby enhancing glycolysis, suppressing OXPHOS, and establishing a metabolic firewall against therapeutic stress [97]

Our structure appears to capture a catalytically competent state where the GSH thiol is in proximity to an arginine, located in TM4, essential for catalysis

When cells fail to neutralize free radicals, there is an imbalance between the radicals and the antioxidant responses, leading to harmful and damaging oxidative stress

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This creates what medical professionals call an adductor strain, though most people simply refer to it as a pulled groin