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Importantly, TB-500 is banned by the World Anti Doping Agency (WADA) [10]

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At doses above 10 mcg/kg, paradoxical hypertension has been observed in the same rodent preparations

In some embodiments, the ratio of a thermoreversible poloxamer to a thickening agent in a formulation that has a pH as described herein is about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1