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Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase

Ethical approval and consent to participate The current study was approved by the Ethics Committee of the Affiliated Fuyang Peoples Hospital of Anhui Medical University before data collection and analysis (No.2021-19)