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The patient originally had cardiac hypertrophy, but following atrioventricular (AV) block and years of ventricular pacing, developed systolic dysfunction, in the form of hypokinetic hypertrophic cardiomyopathy (HCM), as previously described ( iPSCs culture and differentiation iPSC differentiation into cardiomyocytes was performed according to the previously described directed differentiation by modulating Wnt/ -catenin signaling protocol ( Mice experiments All studies involving mice conformed to the Guide for the Care and Use of Laboratory Animals (NIH Publication No
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