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Upon treatment with ferroptosis inhibitors, a significant reduction in the pathophysiological manifestations was observed in the murine models, concomitant with a substantial increase in overall survival rates [76]

Additionally, hepatocytes undergoing ferroptosis release molecules that can activate adjacent immune cells, such as Kupffer cells, thereby influencing hepatic inflammation and fibrotic processes [182]

The basal expression and nuclear binding activities of c-Jun, c-Fos, p50 and p65 are lower in fibroblast cells lacking Nrf1 or Nrf2

helveticus LH166 was obtained from Culture System Inc