36 , 130143.e135 (2024)
In some ways, the lesser degree of obesity and exacerbated metabolic disturbances in these mice resembles the clinical characteristics of Asian patients with T2DM 17,18 , suggesting that Insr P1195L/ +/HFD mice are suitable for investigating the pathophysiology of HFD-sensitive T2DM in humans
Elkelish A, El-Mogy MM, Niedbaa G, Piekutowska M, Atia MA, Hamada MM, et al
J Appl Physiol (1985) 83(6):18571861
Possible synergistic effects of nonesterified fatty acids and lysolecithins, a toxic methionine metabolite, and ammonia in the production of hepatic encephalopathy and schizophrenia
The defective mitophagy observed in EESCs permits the accumulation of dysfunctional mitochondria, which sustains elevated ROS levels and intensifies all ROS-dependent arms of Erastin-induced cell death