However, the requirement for HSL phosphorylation has recently been challenged as studies by the Granneman group elegantly show that direct activation of PNPLA2 in the absence of PKA stimulation is sensitive to HSL inhibition, suggesting that PNPLA2-mediated generation of DAG is sufficient to promote HSL activity (49)
Keshteli AH, Millan B, Madsen KL
With B12, as with many nutrients, the goal is not as much as possible
The Injections: Why Theyre Often the First Line When a significant B12 deficiency is diagnosed, especially if its due to a malabsorption issue, your GP or specialist will almost certainly recommend injections
For someone who hasn't responded adequately to supplements, DSIP represents a more potent intervention
Cyanocobalamin represents the synthetic form most commonly used in supplements and compounded formulations