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A genome-wide screen reveals FSP1 as the warfarin-resistant VKR To identify VKR, we used a genome-wide CRISPR-Cas9 knockout library (Brunello), which is composed of 76,441 single guide RNAs (sgRNAs) targeting 19,114 genes in the human genome 18

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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients