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Taylor JA

PMCID: PMC6822815

GHK-Cu Research# GHK-Cu research spans both laboratory and limited human studies: Wound healing : Accelerated wound closure in animal models and small human studies Skin rejuvenation : Human studies demonstrating improved skin thickness, elasticity, and collagen density with topical application Hair growth : Studies showing increased hair follicle size and proliferation Gene modulation : Comprehensive genomic studies mapping its effects on ~4,000 genes Anti-fibrotic effects : Research suggesting reduction of scar tissue formation GHK-Cu benefits from some human data in dermatological applications and a longer history of commercial use, though large-scale clinical trials remain limited

We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins

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