It is a well-characterized, mechanistically specific peptide with a 30-year research history, a strong clinical safety record from formal trials, and modest but real efficacy data from 12-week studies
Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B12 (see WARNINGS)
(PubMed) Lauer AA, Grimm HS, Apel B, et al
Treated mice show a 15%20% increase in basal metabolic rate and elevated energy expenditure, with effects positively correlated with NNMT inhibition
Additionally, a study that administered vitamin B-12 to rats with a high-fat diet showed that the rats did not gain as much weight as their counterparts who didnt receive the vitamin
Proven strategies include: High-protein diet (1.62.2 g/kg bodyweight) Progressive resistance training Daily step targets (8,00012,000 steps) Calorie deficit of 300500 kcal Consistent sleep (79 hours) Creatine monohydrate, caffeine, and structured programming have significantly more human data than AOD-9604
