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Management of associated conditions is essential: Diabetes control : Pioglitazone and GLP-1 receptor agonists (such as liraglutide or semaglutide) show hepatic benefits in clinical trials, but their use for NASH is off-label in the UK and should be initiated and monitored by specialists after careful riskbenefit discussion

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This maintains cellular regenerative capacity and supports healthy aging

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This form occurs when natural triglycerides are converted to ethyl esters for concentration (as above), but then are re-converted into synthetic triglycerides

Senescent cell accumulation is associated with: chronic inflammation ('inflammaging'), impaired stem cell niches, tumor progression (paradoxically), organ dysfunction, and multiple diseases of aging