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In this dynamic in vitro BBB (DIV-BBB) model, published in 1999, endothelial cells were seeded on the intra-luminal side with astrocytes and pericytes on the extraluminal side

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Clinical trials as mentioned by the research studies have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial)

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References Bankhead, C