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Tumor cells have a unique malignant biological phenotype, that manifests as a continuous proliferation signal, escape from growth inhibition, unlimited replication ability, continuous angiogenesis, resistance to cell death, invasion and metastasis, genomic instability and mutation, immune escape and other biological phenomena (21)
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The elevation, methylmalonic acid indicates decreased B12 function, as normal B12 function would result in a normal level of methylmalonic acid
Another promising area involves combinatorial therapeutic strategies
doi: 10.1186/s12882-024-03781-x 56
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