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The main bias in the association between irAEs and clinical outcomes is the immortal time bias (ITB)

(2011) 301:H64753

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However, despite being highly vascularized, all these regions have little protection from the bloodbrain barrier (BBB) (Duvernoy and Risold 2007

[Abstract]2020 Oct 8;63(19):11085-11099

Subsequently, through the action of divalent metal transporter 1 (DMT1), Fe 2+ enters from the endosomes to the labile iron pool (LIP) in the cytoplasm [71]