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De Simone R, Ajmone-Cat MA, Carnevale D, Minghetti L (2005) Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

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This sex difference disappears after menopause with the incidence of mood disorders becoming similar in men and women, supporting a key role of estrogen in mood disorders [77]

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